My husband and I have each had chronic issues of discomfort -- him with his back and me with my hip. He is a retired physician and I used to help people with pain problems. We were impressed with the presentation on the potential benefits of the Advanced Aminos, but, in truth, while we had hopes, we didn't have much trust. Now, about two weeks into our daily use, we are really surprised at the substantial benefits we are each feeling, him with his back, and me with my hip! Kind of incredible, really.