I have been taking these tablets for about 7 weeks now. Within the first 1 1/2 hours, i physically noticed a very positive difference, i felt more alive, and breathing became easy, and to note, i had no difficulties with breathing before starting taking these. Other Major benefits i have noticed is, I have a lot more energy, i sleep much better, im stronger, my belt is one notch tighter, my arms have grown 1/2 an inch bigger and its all muscle, and im training less!!! These are amazing. I gave a 150 pill bottle to a friend who is 71, who Loves them, he has an active lifestyle, and just the other week, in a single day, he mowed his entire section, weed wacked his small orchid, and along his roadside, something he has not been able to do in one day for about 2 years. My wife is also taking them and finds she has more energy, sleeps better and is looking trimmer :-) Im an ex bodybuilder of 15 years, gave it up in 1999, i took many bodybuilding supplements, including amino acids, and can 100% say, i have Never had such a great result from a supplement... Advanced Amino is, quite simply,, Amazing. Im on an automatic reordering plan, and giving more bottles away for some other friends to try. My 71 year old friend is asking me for more. I have given him the website link :-) A final note to consider, I take only 2 with breakfast and 2 with lunch, which i will, now my new shipment has arrived, increase to 3 with lunch, splitting the intake into breakfast / lunch, energises me through out the day and doesn't compromise my sleep, but rather enhances it. I hope this is helpful and useful information, Cheers.