I purchased these supplements to help with the circulation and tingling in both my feet. After 3 days the tingling lessened significantly. Unfortunately I was having trouble swallowing the large pills. I tried cutting them in half, but still found myself gagging and this was causing me issues with my throat. I contacted the company to see if they had any other format, but they did not. I have not been able to take the pills, so I canÆt say about the long term effect. But from the few days I took them, I think they are good.