I have been taking vitamins, minerals, glandular extracts, and herbs for 40 years, and most of the things I take produce dramatic results - the overshoot effect. Circ02 doesn't seem to do anything I can feel, but the indicator that comes with the packet shows slow improvement. I apparently was really low, and now, after several months, the indicator puts me in the medium range. So, I will keep taking it, even though I'm not sure what it does for me.