I have been taking cir02 for several months, but have not observed any benefit. I tested my saliva with their strip before taking this supplement and I was depleted. After one month of diligently taking the product on daily basis, I still tested depleted. And I am still depleted after several months. I have written Advanced Bionutritionals several times to inquire why this product is not working for me, but no response from them, instead they keep emailing me adverts of the benefits of this product. I wish they can respond to my questions, and would love to speak with them over the phone, I tried calling but can't reach them. I bought a lot of this product and still taking them on daily. I have never missed a day since I started. I am only taking them with hope it might work for me some day as I know the benefits of Nitric Oxide. I still have 5 boxes left as I ordered a lot from them after listening to their presentation. I will continue taking them but will not order more. The excitement made me to buy a lot at one time, but unfortunately this product has not worked for me,