For many years I would get severe cramps in my calves extending to my thighs often. Recently I was also told I had circulation problem in my legs. I started taking taking this product for high blood pressure as several of the drugs were causing me problems. After starting CircO2, a day or two later I had burning sensation in my legs continuously, and I can move my feet in any direction without the cramps. So I think the circulation is improving, also swelling in my one ankle is improved. I believe in time my blood pressure will also improve. My Nitric Oxide test is at a very low level. I will update this review with the improvement. Thank you for an effective product.