I started with am & pm as recommended.... but a bit much for me; probably because of my b12 supplement. I discontinued the supplement, and others, and now just rely on circ02.
I tank the 'am doseage but not the pm.
My eating habit and particular diet ( mediterranian) works well for me energy-wise.
I am 84+, healthy and active... my wife is 85,beautiful and a picture of health, even after putting up with me for 66yrs
Thank you for your product.