Since taking this product I've noticed that I don't have the aching in my knees and hands anymore! I was very skeptical about buying yet another product and having no effect on the real pain, I have! However, to my surprise, I totally forgot about my knees and hands, until it came to mind that I wasn't feeling anything from them and at that time.. that's when I knew, this product is really good! I'm pain-free today, thanks to advanced bionutritionals!